He achieved a scholarship through the Foundation Meyer for higher cultural and artistic education. His live concert performances led him to France, Germany, Italy and Lebanon. He played piano concerts e.g. in Yokohama, Leipzig, Neapel, Nancy and at the festival of the Aix-en-Provence. As a solo player he performed with the “Orchestre de la Garde Républicaine” and with the “Nouvel Ensemble Instrumental du Conservatoire” in Paris, in the Orchestra Sinfonica Abruzzese, in the Accademia Barocca Willelm Hermans in Terni and in the Orchestra del Lazio in Rome. His passion for chamber music expressed oneself in various concerts like for example at the festivals of Beirut, Pézenas and Saint-Jean-de-Luz.

There have been released a number of records with Romain Descharmes, e.g. one CD containing piano works of the beginning of the 20th century and two more together with Sarah Nemtanu (concertmaster of the Orchestre National de France) and the clarinetist Jérôme Comte.